7 21 2015 Target Gene Functions

Today in an effort to better understand what each of my targets may be contributing due to differences in expression, I made up a short list of the genes. I included the full name, general function of the protein, and proteins they make work in concert with. This will help with analysis down the road.

TARGET FUNCTIONS

GABABR

What: Gamma-aminobutyric acid receptor

Function: Receptors receive signals that could be related to signals needed for immediate actions such as closing the shell or moving in response to stimuli

PGE/EP4

What: Prostaglandin E receptor 4 (EP4)

Function: Receptor for Prostaglandin E2 which suppresses inflammation due to injury

HSPb11

What: Heat Shock Protein beta-11

Function: Small Heat Shock Protein also used during gonad development

BMP2

What: Bone Morphogenic Protein 2

Function: Directs calcification in shell creation

PGRP

What: Peptidoglycan recognition protein

Function: Recognition of bacteria in an immune response

Works with: TNFa, HSP70

HSP70

What: Heat Shock Protein 70kDa

Function: Molecular chaperone and protein preservation in heat response

Works with: PGRP

H2A

What: Histone 2A

Function: One of 5 main Histone Proteins involved in the structure of chromatin and the open reading frame of DNA

Works with: H3.3, H2A.V

H2A.V

What: Histone 2A.V

Function: One of 5 main Histone Proteins involved in the structure of chromatin and the open reading frame of DNA

Works with: H2A, H3.3

H3.3

What: Histone 3.3

Function: One of 5 main Histone Proteins involved in the structure of chromatin and the open reading frame of DNA

Works with: H2A, H2A.V

TLR

What: Toll-like Receptor 2

Function: Recognize foreign pathogens and endogenous materials for consumption by phagocytes in early stages of inflammation.

Works with: TNFa

Actin

What: Actin

Function: Globular protein that forms microfilaments

CRAF

What: Tumor Necrosis Factor receptor-associated factor 3

Function: Related to immune response specifically cell death initiation

Works with: NFkBINA

CARM

What: Coactivator-associated arginine methyltransferase 1

Function: Transfers methyl groups to H3 and H4 to change how DNA is bound up in Chromatin

Works with: H3.3, H2A.V, H2A

GRB2

What: Growth factor receptor-bound protein 2

Function: Signal Transduction/Cell Communication

p29ING

What: Inhibitor of growth protein 4

Function: Inhibits cell growth and induces apoptosis