Tuesday, July 21, 2015

7 21 2015 Target Gene Functions

Today in an effort to better understand what each of my targets may be contributing due to differences in expression, I made up a short list of the genes. I included the full name, general function of the protein, and proteins they make work in concert with. This will help with analysis down the road.


TARGET FUNCTIONS

GABABR

What: Gamma-aminobutyric acid receptor
Function: Receptors receive signals that could be related to signals needed for immediate actions such as closing the shell or moving in response to stimuli

PGE/EP4

What: Prostaglandin E receptor 4 (EP4)
Function: Receptor for Prostaglandin E2 which suppresses inflammation due to injury

HSPb11

What: Heat Shock Protein beta-11
Function: Small Heat Shock Protein also used during gonad development

BMP2

What: Bone Morphogenic Protein 2
Function: Directs calcification in shell creation

PGRP

What: Peptidoglycan recognition protein
Function: Recognition of bacteria in an immune response
Works with: TNFa, HSP70

HSP70

What: Heat Shock Protein 70kDa
Function: Molecular chaperone and protein preservation in heat response
Works with: PGRP

H2A

What: Histone 2A
Function: One of 5 main Histone Proteins involved in the structure of chromatin and the open reading frame of DNA
Works with: H3.3, H2A.V

H2A.V

What: Histone 2A.V
Function: One of 5 main Histone Proteins involved in the structure of chromatin and the open reading frame of DNA
Works with: H2A, H3.3

H3.3

What: Histone 3.3
Function: One of 5 main Histone Proteins involved in the structure of chromatin and the open reading frame of DNA
Works with: H2A, H2A.V

TLR

What: Toll-like Receptor 2
Function: Recognize foreign pathogens and endogenous materials for consumption by phagocytes in early stages of inflammation.
Works with: TNFa

Actin

What: Actin
Function: Globular protein that forms microfilaments

CRAF

What: Tumor Necrosis Factor receptor-associated factor 3
Function: Related to immune response specifically cell death initiation
Works with: NFkBINA

CARM

What: Coactivator-associated arginine methyltransferase 1
Function: Transfers methyl groups to H3 and H4 to change how DNA is bound up in Chromatin
Works with: H3.3, H2A.V, H2A

GRB2

What: Growth factor receptor-bound protein 2
Function: Signal Transduction/Cell Communication

p29ING

What: Inhibitor of growth protein 4
Function: Inhibits cell growth and induces apoptosis

No comments:

Post a Comment